Heterocyclic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/68 (2006.01) A61K 31/44 (2006.01) A61K 31/675 (2006.01) C07D 213/85 (2006.01) C07D 213/89 (2006.01) C07D 309/38 (2006.01) C07D 309/40 (2006.01) C07D 401/02 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 409/02 (2006.01) C07F 9/576 (2006.01) C07F 9/58 (2006.01)

Patent

CA 2078147

2078147 9113873 PCTABS00007 A compound of formula (I), wherein R1 represents a hydrogen or halogen atom, or a cyano group; R2 represents an optionally substituted carbocyclic group having 6 to 10 ring atoms and containing at least one aromatic ring; an optionally substituted heterocyclic group having 5 to 10 ring atoms, including 1 to 4 heteroatoms selected from O, N and S, and containing at least one aromatic ring; or an optionally substituted C3-6cycloalkyl, C3-6cycloalkyl-, C1-6alkyl, or C1-10alkyl group; R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom, or a C1-6alkyl group optionally substituted by 1 to 3 halogen atoms; and R5 represents a hydrogen atom, a hydroxyl group, or a C1-6alkyl group, optionally substituted by hydroxy, carboxy, amino or mono- or di-(C1-4)alkyl amino, and salts and other physiologically functional derivatives thereof. The compounds are useful in the treatment of parasitic infections e.g. malaria, coccidiosis and Pneumocystis carinii pneumonia.

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