C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/44 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61P 25/16 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2459161
The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1 B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.
La présente invention concerne des procédés et des compositions pour moduler l'activité de phosphodiestérase 1 B (PDE1B) dans les voies de signalisation intracellulaire, y compris mais de façon non limitative, les voies de signalisation intracellulaire de dopamine D1. L'invention concerne aussi des procédés et des compositions pour moduler les activités des molécules de signalisation intramoléculaires, y compris mais de façon non limitative, DARPP-32 et le récepteur AMPA GluR1, via la modulation de PDE1B. L'invention concerne aussi des compositions pharmaceutiques et des procédés de criblage à la recherche des composés modulant l'activité de PDE1B, ainsi que des procédés pour traiter ou alléger les symptômes d'un trouble, y compris mais de façon non limitative, un trouble lié à PDE1B ou un trouble des voies de signalisation intracellulaire de dopamine D1, de préférence mais de façon non limitative, un inhibiteur de PDE1B ou un agent qui réduit la production du PDE1B.
Greengard Paul
Repaske David
Snyder Gretchen
Children's Hospital & Medical Center
Kirby Eades Gale Baker
The Rockefeller University
LandOfFree
Phosphodiesterase activity and regulation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phosphodiesterase activity and regulation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphodiesterase activity and regulation of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2012054