C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2718741
The invention relates to a method for in vitro detection and/or differentiation and/or observation of the progression of pathophysiological states (e.g. SIRS or SEPSIS) by way of nucleic acid samples, determination of gene activities by way of a plurality of polynucleotides, determination of gene activity of at least one internal reference gene and formation of an index value from the individually determined, normalized gene activities of a multi-gene biomarker which indicates the pathophysiological state.
L'invention concerne un procédé de détection et/ou de différenciation et/ou d'observation de l'évolution d'états pathophysiologiques au moyen d'échantillons d'acides nucléiques, de détermination d'activités géniques au moyen d'une pluralité de polynucléotides, de détermination d'activités géniques d'au moins un gène de référence interne ainsi que d'élaboration d'une valeur d'indice à partir des différentes activités géniques normalisées déterminées d'un biomarqueur multigénique qui indique l'état pathophysiologique.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Sirs-Lab Gmbh
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