A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 31/07 (2006.01) A61K 31/20 (2006.01) A61K 31/56 (2006.01) A61K 31/59 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01)
Patent
CA 2153794
The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin D3, and Vitamin D3 derivatives which are capable of activating the intracellular Vitamin D3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response aumenting agent. The immune response augmenting agent enhances T cell lymphokine production. Suitable immune response augmenting agents include, but are not limited to, DHEA and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S),16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.bromo-DHEA-S, and 7-oxo- DHEA-S.
Araneo Barbara A.
Daynes Raymond A.
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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