Polyamine thiols as radioprotective agents

Details Polyamine thiols as radioprotective agents Polyamine thiols as radioprotective agents

C - Chemistry, Metallurgy

07

C

C07C 323/31 (2006.01) A61K 31/135 (2006.01) A61K 31/66 (2006.01) C07C 323/25 (2006.01) C07C 323/32 (2006.01) C07C 323/34 (2006.01) C07F 9/165 (2006.01)

Patent

CA 2059817

The present invention relates to certain polyamine thiols of the formula (1) or (2) <See formula I> <See formula II> wherein n is an integer from 0 to 3, m is an integer from 4 to 9, Z is a C2-C6 alkylene group, A is H, -SH, -SPO3H2, -N(CH2)q-SH, -N(CH2)q-SPO3H2, wherein q is an integer 2 to 4, and B1 and B2 are each independently H, -(CH2)q-SH, or -(CH2)q-SPO3H2. with the proviso that at least one of A, B1 and B2 is other than H, which are useful as radioprotective agents.

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