Process for producing...

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C - Chemistry, Metallurgy

07

D

C07D 211/32 (2006.01)

Patent

CA 2624805

1-Benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl~piperidine or a solvate thereof is catalytically hydrogenated in the presence of a palladium-alumina catalyst. According to need, the resultant reaction product is converted to a hydrochloride. Thus, 1-benzyl-4-[(5,6-dimethoxy-1~indanon)-2- yl]methylpiperidine or a hydrochloride thereof, which are useful as a medicine, can be produced as a high-purity compound by a safer and easy operation suitable for industrial production.

Selon la présente invention, la 1-benzyl-4-[(5,6-diméthoxy-1-indanon)-2-ylidène]méthyl­pipéridine ou son solvate est catalytiquement hydrogéné en présence d'un catalyseur de palladium sur alumine. Selon le besoin, le produit de réaction résultant est converti en un chlorhydrate. Ainsi, la 1-benzyl-4-[(5,6-diméthoxy-1­indanon)-2-yl]méthylpipéridine ou son chlorhydrate, qui est utile en tant que médicament, peut être produit sous la forme d~un composé de grande pureté par une transformation sans risque et facile appropriée pour une production industrielle.

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