Phenyl-piperazin methanone derivatives

Details Phenyl-piperazin methanone derivatives Phenyl-piperazin methanone derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2589192

The present invention relates to compounds of the general formula (I) wherein R1 is the group (A) or (B) or (C) or (D); R2 is a non aromatic heterocycle, or is OR' or N(R")2; R' is lower alkyl, lower alkyl substituted by halogen or - (CH2)n-cycloalkyl; R" is lower alkyl; R3 is NO2, CN or SO2R'; R4 is hydrogen, hydroxy, halogen, NO2, lower alkyl, lower alkyl, substituted by halogen, lower alkoxy, SO2R' or C(O)OR"; R5/R6/R7 are hydrogen, halogen, lower alkyl or lower alkyl, substituted by halogen; X1/X1~ are CH or N, with the proviso that X1/X1~ are not simultaneously CH; X2 is O, S, NH or N(lower alkyl); n is 0, l or 2; and to pharmaceutically active acid addition salts and to their use in the treatment of neurological and neuropsychiatric disorders.

L'invention se rapporte à des composés de la formule générale (1) dans laquelle R1 représente le groupe (A) ou (B) ou (C) ou (D); R2 est un hétérocycle non aromatique, ou est OR' ou N(R")2; R' est un alkyle inférieur, un alkyle inférieur substitué par halogène ou un -(CH2)n-cycloalkyle; R" est un alkyle inférieur; R3 est NO2, CN ou SO2R'; R4 est un hydrogène, hydroxy, halogène, NO2, alkyle inférieur, alkyle inférieur substitué par halogène, alcoxy inférieur, SO2R' ou C(O)OR"; R5/R6/R7 sont un hydrogène, halogène, alkyle inférieur ou alkyle inférieur substitué par halogène; X1/X1' sont CH ou N, à condition que X1/X1' ne soient pas simultanément CH; X2 est O, S, NH ou N(alkyle inférieur); n représente 0, l ou 2; et à des sels d'addition acides pharmaceutiquement actifs et à leur utilisation dans le traitement des troubles neurologiques et neuropsychiatriques.

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