A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 47/24 (2006.01)
Patent
CA 2705031
Compositions, preparation methods and potential applications of gel-stabilized liposomes with high degree of entrapment efficiency and stability are described. In particular, the novel liposome system comprises liposomes that each encapsulate an internal thermo-transformable hydrogel, dispersed and suspended in a continuous external thermo-reversible hydrogel phase. Agents, such as active agents, are encapsulated in the internal hydrogel core or in the lipid bilayer, or multilayers, depending on whether the active agent is water or lipid soluble, respectively.
L'invention concerne des compositions, des procédés de préparation et des applications potentielles de liposomes stabilisés par un gel qui présentent une capacité de piégeage et de stabilité élevées. En particulier, le nouveau système de liposomes comprend des liposomes qui encapsulent chacun un hydrogel interne thermotransformable, dispersé et en suspension dans une phase hydrogel externe continue thermoréversible. Des agents, tels que des principes actifs, sont encapsulés dans le noyau d'hydrogel interne ou dans la bicouche ou la multicouche lipidique, selon que le principe actif est soluble dans l'eau ou dans les lipides, respectivement.
Beijing Snowle Biotech Co. Ltd.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Lipodur Pharmaceutical Inc.
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