Polymeric composition for solubilizing poorly water soluble...

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 71/02 (2006.01) A61K 9/107 (2006.01) A61K 47/30 (2006.01) C08L 67/04 (2006.01) C08L 101/16 (2006.01)

Patent

CA 2381729

A composition capable of forming a micelle in body fluids or in an aqueous medium and that can be injected into the body undiluted or as a diluted solution in an aqueous medium and method for preparation thereof are disclosed. The composition comprises an amphiphilic block copolymer having a hydrophilic poly(alkylene glycol) component and hydrophobic biodegradable polymer component, contained in a poly(ethylene glycol) medium. Such composition is useful in the solubilization and administra-tion of a poorly water soluble drug.

L'invention concerne une composition, capable de former une micelle dans des fluides organiques ou dans un milieu aqueux, et que l'on peut injecter dans le corps, non diluée ou en tant que solution diluée dans un milieu aqueux. L'invention concerne également un procédé de préparation de cette composition, laquelle comprend un copolymère séquencé amphiphile possédant un constituant hydrophile poly(alkylène glycol) et un constituant polymère hydrophobe, biodégradable, contenu dans un milieu de poly(éthylène glycol). Une telle composition est utile dans la solubilisation et l'administration d'un médicament faiblement soluble dans l'eau.

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