Bicyclic and tricyclic heteroaromatic compounds

Details Bicyclic and tricyclic heteroaromatic compounds Bicyclic and tricyclic heteroaromatic compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) A61P 25/00 (2006.01) C07D 217/26 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 237/00 (2006.01) C07D 237/30 (2006.01) C07D 249/00 (2006.01) C07D 417/04 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2388593

Disclosed are compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors and re therefore useful in the treatment of central nervous system (CNS) diseases and as probes for the localization of GABAA receptors in tissue samples. Also disclosed are intermediates useful in the preparation of these compounds.

On décrit des composés de formule (I) ainsi que leurs sels pharmaceutiquement acceptables. Dans la formule W, Q, X, X¿1?, Y et Z sont tels que décrits dans le descriptif. Ces composés se lient avec une forte sélectivité et/ou une grande affinité au site benzodiazépine des récepteurs GABA¿A? et sont par conséquent utiles dans le traitement des maladies du système nerveux central (SNC) et en tant que sondes permettant de localiser les récepteurs GABA¿A? dans des échantillons de tissus. On décrit également des intermédiaires utiles dans la préparation de ces composés.

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