C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2221521
The present disclosure describes a method for probing the integrity of a Y chromosome utilizing multiplex PCR reactions which amplify specific regions of the human Y chromosome which have been linked to normal fertility in human males. The method is capable of detecting deletion mutations within the Y chromosome which are predictive of human male infertility. A kit containing reagents needed to practice the method is also disclosed.
La présente invention concerne un procédé permettant de tester l'intégrité d'un chromosome Y par des réactions PCR multiplex amplifiant des régions spécifiques du chromosome Y humain pour lesquelles on a établi une relation avec la fertilité normale chez le sujet masculin. Ce procédé permet de détecter des mutations par délétion à l'intérieur du chromosome Y, mutations qui permettent de prédire une infertilité chez le sujet masculin. L'invention concerne également une trousse contenant les réactifs nécessaires à la mise en oeuvre dudit procédé.
Agoulnik Alexander I.
First Marijo K.
Muallem Ariege
Borden Ladner Gervais Llp
Promega Corporation
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