C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2520372
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured laminin with substantially greater affinity than to the native form of laminin. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo.
L'invention concerne des procédés permettant d'inhiber l'angiogenèse dans un tissu. Lesdits procédés consistent à administrer un antagoniste qui se fixe de manière spécifique sur une laminine protéolysée ou dénaturée présentant une affinité sensiblement supérieure à la forme native de laminine. L'invention concerne également des procédés d'utilisation desdits antagonistes dans le traitement thérapeutique de la croissance tumorale, des métastases tumorales ou de la resténose. L'invention concerne également des procédés d'utilisation desdits antagonistes en tant que marqueurs diagnostiques de l'angiogenèse dans des tissus sains ou malades, in vivo et ex vivo.
Akalu Abebe
Brooks Peter C.
New York University
Smart & Biggar
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