A novel b-lymphoma cell line and antigen

Details A novel b-lymphoma cell line and antigen A novel b-lymphoma cell line and antigen

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2142989

This invention provides an IL-6 dependent B-cell lymphoma cell line designated DS-1 deposited with the American Type Culture Collection, wherein the cell line is reactive with a monoclonal antibody produced by a hybridoma cell line designated 10D2F6 deposited with the American Type Culture Collection. The invention also provides a purified antigen reactive with a monoclonal antibody produced by 10D2F6. The antigen also exists on DS-1. Also provided is a method of detecting the presence of an antigen-stimulated T-cell comprising detecting the presence of the antigen on a lymphocyte. In addition, the invention pro- vides a method of detecting the presence of a neoplastic cell comprising detecting the presence of the antigen on a cell which is not a normal T-cell.

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