Heterocyclic compounds and compositions as c-kit and pdgfr...

Details Heterocyclic compounds and compositions as c-kit and pdgfr... Heterocyclic compounds and compositions as c-kit and pdgfr...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2714700

The invention provides a novel class of compounds of Formula I: (I) pharmaceutical compositions comprising such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR.alpha. and PDGFR.beta.kinases.

L'invention concerne une nouvelle classe de composés, de formule I : (I) des compositions pharmaceutiques comprenant de tels composés pour traiter ou empêcher des maladies ou des troubles associés à une activité kinase anormale ou dérégulée, notamment des maladies ou troubles qui impliquent une activation anormale de c-kit, PDGFRa et PDGFRß kinases.

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