Screen for compounds with affinity for rna

Details Screen for compounds with affinity for rna Screen for compounds with affinity for rna

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 21/76 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2203832

The present invention provides methods for high-throughput screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve measuring the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA conformation.

L'invention concerne des procédés permettant d'effectuer un criblage à rendement élevé, afin de rechercher des composés bioactifs, en particulier, ceux qui se fixent à des séquences d'ARN présentes dans la pathogénèse de maladies ou dans la régulation d'une fonction physiologique. Ces procédés consistent à mesurer la conformation d'une cible d'ARN en présence et en l'absence de ligands de contrôle, puis à identifier en tant que ligand, tout ligand de contrôle provoquant une modification mesurable dans la conformation de l'ARN cible.

Affiliated with

Also associated with

Rating

Screen for compounds with affinity for rna does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Screen for compounds with affinity for rna, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screen for compounds with affinity for rna will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2014514