Sustained release formulations for 24 hour release of...

Details Sustained release formulations for 24 hour release of... Sustained release formulations for 24 hour release of...

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 31/138 (2006.01)

Patent

CA 2171844

A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic cross-linking agent, and metoprolol provides release of metoprolol for at least about 24 hours. In certain embodiments, the sustained release formulation further includes a hydrophobic material.

Une forme galénique solide à libération prolongée s'administrant par voie orale d'une formulation pharmaceutique de métoprolol comprend un exicpient de libération prolongée comportant un agent de gélification, un diluant pharmaceutique inerte, un agent de réticulation cationique et du métoprolol et permet de libérer le métoprolol pendant une durée de 24 heures environ. Dans certains modes de réalisation, la formulation à libération prolongée comprend, de plus, un matériau hydrophobe.

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