Modified chimeric polypeptides with improved pharmacokinetic...

Details Modified chimeric polypeptides with improved pharmacokinetic... Modified chimeric polypeptides with improved pharmacokinetic...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07K 14/71 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2588221

Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.

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