Substituted benzocycloheptapyridine derivatives useful for...

Details Substituted benzocycloheptapyridine derivatives useful for... Substituted benzocycloheptapyridine derivatives useful for...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) C07D 401/12 (2006.01) C07D 409/14 (2006.01) C07F 9/59 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2264508

Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R1, R3 and R4 are each independently selected from halo. W represents a group selected from: -SO2R12 or -P(O)R13R14. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

L'invention porte sur de nouveaux composés de formule (1.0) représentés par les composés des formules (1.4) et (1.5) dans lesquelles R?1¿, R?3¿ et R?4¿ sont chacun sélectionnés indépendamment parmi halo. W représente un groupe choisi parmi: -SO¿2?R?12¿ et -P(O)R?13¿R?14¿. L'invention porte également sur des procédés d'inhibition de la farnésyl transférase, et de la croissance des cellules anormales par exemple des cellules tumorales.

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