Bacterial elastin binding protein, nucleic acid sequence...

Details Bacterial elastin binding protein, nucleic acid sequence... Bacterial elastin binding protein, nucleic acid sequence...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 39/085 (2006.01) A61K 39/40 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) C12N 5/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247072

A microbial surface component recognizing adhesive matrix molecules (MSCRAMM) is disclosed which is characterized by its ability to bind to elastin, its inhibited activity in the presence of SDS and its enhanced activity in the presence of thiol reductants. More particularly, the MSCRAMM is bacterial in origin and is a member of the family of elastin binding proteins. In one embodiment, the MSCRAMM comprises a polypeptide having an amino acid sequence defined herein as SEQ ID NO:2, and extends to active fragments thereof. The role of MSCRAMMs in bacterial infection and its sequelae and related conditions is noted and the MSCRAMM may be prepared and used in diagnostic procedures and tests, including drug discovery assays, as well as in pharmaceutical compositions applicable for corresponding therapeutic methods. Both agonists and antagonists of the MSCRAMM are proposed and illustrated.

Composant de la surface microbienne reconnaissant des molécules adhésives de la matrice (CSMRMAM) qui se caractérise par sa capacité de se lier à l'élastine, l'inhibition de son activité en présence de laurylsulfate de sodium et l'accroissement de son activité en présence d'un agent réducteur de thiol. Plus particulièrement, le CSMRMAM est d'origine bactérienne et fait partie de la famille des protéines fixatrices de l'élastine. Dans une matérialisation, le CSMRMAM contient un polypeptide ayant une séquence d'acides aminés définie ici comme SEQ ID NO:2, et s'applique aux fragments actifs de celui-ci. Le rôle du CSMRMAM dans l'infection bactérienne et ses séquelles et les procédés connexes est noté et le CSMRMAM peut être préparé et utilisé dans les interventions et les tests diagnostiques, dont les tests de recherche de médicaments, ainsi que dans les compositions pharmaceutiques applicables à des méthodes thérapeutiques correspondantes. Des agonistes et des antagonismes du CSMRMAM sont proposés et présentés.

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