Use of antisense oligonucleotides or sirna to suppress...

Details Use of antisense oligonucleotides or sirna to suppress... Use of antisense oligonucleotides or sirna to suppress...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 27/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2517974

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.

La présente invention concerne un facteur 5A d'initiation eucaryotique spécifique à l'apoptose (eIF-5A), désigné comme facteur d'apoptose 5A1 ou tout simplement facteur 5A1, des acides nucléiques et des polypeptides de facteur d'apoptose 5A1, ainsi que des procédés pour inhiber ou supprimer l'apoptose dans des cellules au moyen de nucléotides antisens ou siARN, afin d'inhiber l'expression du facteur 5A1. La présente invention concerne également des procédés pour supprimer ou inhiber l'expression de cytokines pro-inflammatoires en inhibant l'expression du facteur d'apoptose 5A.

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