Transgenic plants co-expressing a functional human 2-5a system

Details Transgenic plants co-expressing a functional human 2-5a system Transgenic plants co-expressing a functional human 2-5a system

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A01H 5/00 (2006.01) C12N 9/12 (2006.01) C12N 9/22 (2006.01) C12N 15/52 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2224004

Novel transgenic plants having the ability to express a functional 2-5A system, i.e., a 2-5A synthetase which produces 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A) in response to double-stranded RNA (dsRNA), and a 2-5A- dependent (RNase L), are disclosed. The novel transgenic plants expressing the functional 2-5A system, such as novel transgenic tobacco plants, are immune to and resistant against viral infection. When the novel transgenic tobacco plants are exposed to three different types of plant viruses, i.e., TMV, TEV and AIMV, such viral exposure leads to necrotic local lesions in such transgenic tobacco plants instead of typical systemic infections.

L'invention concerne de nouvelles plantes transgéniques capables d'exprimer un système 2-5A fonctionnel, c'est-à-dire, une synthétase de 2-5A produisant des oligoadénylates (2-5A) à liaison 2', 5', 5'-phosphorylées en réaction à un ARN bicaténaire et à la (Rnase L) dépendante de 2-5A. Les nouvelles plantes transgéniques exprimant le système 2-5A fonctionnel, telles que de nouveaux plants de tabac transgéniques, présentent une immunité et une résistance à l'infection virale. Quand ces nouveaux plants de tabac transgéniques sont exposés à trois types différents de virus de plantes, notamment TMV, TEV et AIMV, cette exposition au virus provoque des lésions nécrotiques locales dans ces plants de tabac transgéniques au lieu d'infections systémiques typiques.

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