Substituted aminoalkanephosphonic acids

Details Substituted aminoalkanephosphonic acids Substituted aminoalkanephosphonic acids

C - Chemistry, Metallurgy

07

F

C07F 9/6509 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2269807

Compounds have the formula (I), in which R1 stands for hydroxy or an aliphatic, araliphatic or aromatic radical; X stands for a bivalent aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic, heteroarylaliphatic or aromatic radical; R2 stands for hydrogen or an aliphatic or araliphatic radical; elk stands for lower alkylidene; and R3, R4 and R5 independently represent hydrogen, lower alkyl, halogen, trifluoromethyl, cyano or nitro. These compounds and their salts may be used for treating pathological conditions which respond to the blocking of exciter amino acid receptors, and for producing pharmaceutical compositions.

Les composés décrits répondent à la formule (I), dans laquelle R1 désigne hydroxy ou un radical aliphatique, araliphatique ou aromatique; X désigne un radical aliphatique, cycloaliphatique, cycloaliphatique-aliphatique, araliphatique, hétéroarylaliphatique ou aromatique bivalent; R2 désigne hydrogène ou un radical aliphatique ou araliphatique; alk désigne alkylidène inférieur; et R3, R4 et R5 désignent indépendamment les uns des autres hydrogène, alkyle inférieur, halogène, trifluorométhyle, cyano ou nitro. Ces composés et leurs sels peuvent être utilisés pour traiter des états pathologiques qui réagissent au blocage des récepteurs d'acides aminés excitateurs, et pour produire des préparations pharmaceutiques.

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