Improved process for preparing zolpidem

Details Improved process for preparing zolpidem Improved process for preparing zolpidem

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) C07C 233/06 (2006.01) C07C 235/74 (2006.01) C07D 235/00 (2006.01)

Patent

CA 2445766

The invention relates to a method for the production of a compound of formula (I), wherein a compound of formula (II), in which R1 represents chlorine, bromine, iodine, -O-COCH3, -tosylate or -mesylate, is reacted with a compound of formula (III), optionally in a suitable diluting agent and/or in the presence of a suitable additional reactant or catalyst, wherein the reaction is carried out at a temperature ranging from 20 to 80~ C.

L'invention concerne un procédé de production d'un composé de formule (I), consistant à faire réagir un composé de formule (II), dans laquelle R?1¿ représente un atome de chlore, de brome ou d'iode, -O-COCH¿3?, -tosylate ou -mésylate, avec un composé de formule (III), éventuellement dans un agent de dilution adapté et/ou en présence d'un catalyseur ou d'un réactif additionnel adapté, la réaction ayant lieu à une température comprise entre 20 et 80·C.

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