Tenascin-c nucleic acid ligands

Details Tenascin-c nucleic acid ligands Tenascin-c nucleic acid ligands

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380473

Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.

L'invention concerne des méthodes d'identification et de préparation de ligands d'acide nucléique à la ténascine-C. Elle concerne également des ligands spécifiques de l'ARN à la ténascine-C identifiés selon la méthode SELEX. L'invention concerne en outre des méthodes pour détecter la présence d'un état pathologique dans un tissu biologique dans lequel la ténascine-C est exprimée.

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