C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/428 (2006.01) A61K 31/4439 (2006.01) A61K 31/47 (2006.01) A61P 31/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2607089
Compounds having the formula (I) wherein A, m and R1 are herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process.
L'invention concerne des composés représentés par la formule I dans laquelle A, m et R1 sont tels que définis dans la description, lesdits composés étant des inhibiteurs de la polymérase NS5b du virus de l'hépatite C. L'invention concerne également des compositions et des méthodes destinées à inhiber la répétition de l'hépatite, des méthodes de fabrication desdits composés, et des intermédiaires de synthèse utilisés dans lesdites méthodes. Formule (I)
Blake James F.
Fell Jay Bradford
Fischer John P.
Hendricks Robert Than
Spencer Stacey Renee
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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