Hyaluronan receptor expressed in human umbilical vein...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2214995

The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (HR) form human umbilical vein endothelial cells. The present invention also privdes for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for the detecting and the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.

L'invention concerne des séquences nucléotidiques et d'acides aminés qui identifient et codent le récepteur d'hyaluronan (HR) des cellules endothéliales de la veine ombilicale de l'humain. Elle porte aussi sur des molécules antisens dirigées contre les séquences nucléotidiques qui codent HR, des facteurs d'expression pour la production d'HR purifié, des anticorps capables de se fixer spécifiquement à HR, des sondes d'hybridation ou des oligonucléotides pour la détection et la régulation positive des séquences nucléotidiques codant HR, sur des cellules hôtes manipulées génétiquement pour l'expression d'HR, des essais diagnostiques pour les cellules et/ou tissus métastatiques ou enflammés, activés et angiogéniques, basés sur les molécules d'acide nucléique codant HR et sur des anticorps capables de se fixer spécifiquement audit récepteur.

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