Sulfonamide compounds or salts thereof

Details Sulfonamide compounds or salts thereof Sulfonamide compounds or salts thereof

C - Chemistry, Metallurgy

07

C

C07C 311/21 (2006.01) A61K 31/341 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/443 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 13/02 (2006.01) A61P 13/08 (2006.01) A61P 13/10 (2006.01) A61P 43/00 (2006.01) C07D 213/71 (2006.01) C07D 277/20 (2006.01) C07D 277/36 (2006.01) C07D 277/56 (2006.01) C07D 307/64 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2728511

[Object] A compound which is useful as an EP1 receptor antagonist is provided. [Means for Solution] The present inventors investigated EP 1 receptor antagonists, and confirmed that a compound having a sulfonamide structure, in which the nitrogen atom of the sulfonamide structure is substituted with 2-fluoropropyl group, 3- fluoro-2-methylpropyl group or the like, has a potent EP 1 receptor antagonistic action, thereby completing the present invention. The sulfonamide compound of the present invention has a potent EP1 receptor antagonistic action and can be used as an agent for preventing and/or treating a lower urinary tract symptom or the like.

L'invention porte sur un composé utile comme antagoniste des récepteurs EP1. Des études sont effectuées sur les antagonistes des récepteurs EP1, et il est confirmé qu'un composé ayant une structure de sulfonamide dans laquelle un atome d'azote dans la structure de sulfonamide est substitué par un groupe 2-fluoropropyle, un groupe 3-fluoro-2-méthylpropyle ou similaires a une activité antagoniste puissante sur un récepteur EP1. Le composé sulfonamide a une activité antagoniste puissante sur un récepteur EP1 et, par conséquent, peut être utilisé comme agent prophylactique et/ou thérapeutique pour un symptôme du tractus urinaire inférieur ou similaire.

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