Substituted pyrimidinones and pyrimidinthiones

Details Substituted pyrimidinones and pyrimidinthiones Substituted pyrimidinones and pyrimidinthiones

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

D

IPC codes

C07D 417/14 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) C07D 239/46 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Type

Patent

Patent number

CA 2477008

Description

This invention relates to substituted pyrimidinone and pyrimidithione derivatives that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.

L'invention concerne de dérivés de pyrimidinone et de pyrimidithione substitués qui se lient avec une affinité élevée à des récepteurs du facteur de libération de corticotropine (CRF1), notamment des récepteurs de CRF1 humain. L'invention concerne également des méthodes d'utilisation des composés de l'invention pour traiter un trouble ou un état dont le traitement peut être effectué ou facilité par antagonisme du récepteur de CRF, tels que des troubles ou des maladies CNS, notamment des états d'anxiété et des troubles associées à la dépression et au stress.

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