A method of affinity separation and ligands for use therein

Details A method of affinity separation and ligands for use therein A method of affinity separation and ligands for use therein

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01) C07K 1/22 (2006.01) C07K 14/00 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C40B 50/00 (2006.01)

Patent

CA 2633345

The present invention relates to methods of affinity separation wherein the affinity ligand is an immobilised proteinaceous ligand wherein one or more of its asparagine (Asn) residues has been modified. Methods of making a stabilised combinatorial protein comprising the steps of: a) modification of Asn residues within a protein molecule to increase stability of the protein in alkaline conditions; and b) randomisation of the protein molecule to modify its binding characteristics and combinatorial proteins wherein in a step separate from the randomisation step, the stability of the protein in alkaline conditions has been increased by modifying one or more of its Asn residues are also described.

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