Diagnostic and treatment methods involving the cystic...

Details Diagnostic and treatment methods involving the cystic... Diagnostic and treatment methods involving the cystic...

C - Chemistry, Metallurgy

12

N

530/13, 167/130,

C12N 15/12 (2006.01) A61K 9/127 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2037478

ABSTRACT Disclosed are full length isolated DNAs encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein and a variety of mutants thereof. Also disclosed are antibodies specific for various CFTR domains and methods for their production. Expression of CFTR from cells transformed with these CFTR genes or cDNAs demonstrate surprising CFTR intracellular distributions and results thereby providing for new diagnostic and therapeutic procedures.

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