A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/711 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) C12N 9/22 (2006.01)
Patent
CA 2618288
The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention relates to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues. More particularly this invention relates to the use of antisense oligonucleotides having arabinose sugars to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc.
Arion Dominique
Borkow Gadip
Damha Massad Jose
Noronha Anne M.
Parniak Michael A.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Mcgill
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