Process for the preparation of hypoallergenic major birch...

Details Process for the preparation of hypoallergenic major birch... Process for the preparation of hypoallergenic major birch...

C - Chemistry, Metallurgy

07

K

C07K 14/415 (2006.01) C07K 1/113 (2006.01) C07K 1/36 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2477409

The invention relates to a method for producing hypoallergenic major birch pollen allergens by means of at least one chromatographic clean-up step, using essentially non-buffered aqueous bases as mobile solvents, followed by neutralisation. The hypoallergenic major birch pollen allergens are characterised by a lack of, or at least reduced, immunoglobulin-E binding and simultaneous therapeutically relevant T-cell stimulation. Said allergens can thus be used in specific immunotherapy as therapeutic agents having few side effects.

La présente invention concerne un procédé pour produire des allergènes majeurs des pollens de bouleau hypoallergéniques grâce à une ou plusieurs étapes de nettoyage chromatographique par utilisation de bases aqueuses sensiblement non tamponnées en tant que bases mobiles, suivie(s) d'une neutralisation. Les allergènes majeurs des pollens de bouleau hypoallergéniques se caractérisent par une absence ou au moins une diminution de la liaison E de l'immunoglobuline accompagnée de la stimulation significative du point de vue thérapeutique des lymphocytes T. Lesdits allergènes peuvent de ce fait être utilisés en immunothérapie spécifique en tant qu'agents thérapeutiques ayant peu d'effets secondaires.

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