Peptides inhibiting phospholipase c

Details Peptides inhibiting phospholipase c Peptides inhibiting phospholipase c

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C12N 9/20 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189674

Peptides inhibiting phospholipase C which are represented by general formula (I), wherein n represents 0 or 1; J1 and J2 represent each hydrogen or form together a single bond; W represents hydrogen, optionally substituted alkanoyl, optionally substituted aroyl or coumaryl; X represents a single bond, -Leu- or -Ser-Leu-Val-Glu-Leu-Val-Ser-Tyr-Tyr-Glu-Lys-His-Ala-Leu optionally having the deletion, insertion or replacement of at least one amino acid residue; Y represents a single bond or -Pro-Val-; R1 represents hydrogen, optionally substituted alkyl or optionally substituted aryl; and R2 represents optionally substituted alkyl or optionally substituted aryl.

Peptides inhibant la phospholipase C, représentés par la formule générale (I), dans laquelle n vaut 0 ou 1; J?1¿ et J?2¿ représentent chacun hydrogène ou forment ensemble une liaison simple; W représente hydrogène, alcanoyle éventuellement substitué, coumaryle ou aroyle éventuellement substitué; X représente une liaison simple, -Leu- ou -Ser-Leu-Val-Glu-Leu-Val-Ser-Tyr-Tyr-Glu-Lys-His-Ala-Leu, présentant éventuellement la délétion, l'insertion ou le remplacement d'au moins un reste aminoacide; Y représente une liaison simple ou -Pro-Val-; R?1¿ représente hydrogène, ou alkyle ou aryle éventuellement substitué; et R?2¿ représente alkyle ou aryle éventuellement substitué.

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