Composite antibodies of human subgroup iv light chain...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2121041

This invention concerns a subset of composite Hum4 V L, V H .alpha.TAG antibody with high affinities to a high molecular weight; tumor-associated sislylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V L segments derived from the human subgroup IV germline gene and (2) a V H segment which is capable of combining with the V L to form a three dimensional structure having the ability to bind TAG-72. in vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.

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