New lipopolyamines,their preparation and the use thereof

Details New lipopolyamines,their preparation and the use thereof New lipopolyamines,their preparation and the use thereof

C - Chemistry, Metallurgy

07

C

C07C 211/14 (2006.01) A61K 9/127 (2006.01) A61K 47/18 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 217/42 (2006.01) C07C 219/06 (2006.01) C07C 229/16 (2006.01) C07C 237/10 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2299429

The invention relates to novel lipopolyamines (including their salts), characterised by a symmetrical, highly flexible lipophilic component with a buffering capacity at physiological pH, and to their use for funnelling biologically active materials such as DNA, RNA, ribozymes, antisense DNA, peptides and proteins into eukaryotic cells in vivo or in vitro.

L'invention concerne de nouvelles lipopolyamines (y compris leurs sels) caractéristées par une fraction lipophile hautement flexible et symétrique ayant une capacité de tamponnage pour un pH physiologique. L'invention concerne également leur utilisation pour transporter, in vivo ou in vitro, des matières biologiquement actives, par exemple, l'ADN, l'ARN, des ribozymes, l'ADN anti-messager, des peptides et des protéines à l'intérieur de cellules eucaryotes.

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