C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/04 (2006.01) C07D 231/54 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2398446
Amino-pyrazole compounds of formula (I), that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin- dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylatic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés d'amino-pyrazole qui modulent et/ou inhibent l'activité des protéines kinases. Ces composés et les compositions pharmaceutiques les contenant sont capables d'agir sur l'activité de kinases cycline-dépendantes et/ou d'inhiber cette dernière, modifiant et/ou inhibant ainsi une prolifération cellulaire indésirable. L'invention concerne également l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant les présents composés, ainsi que des méthodes de traitement du cancer et d'autres maladies associées à une angiogénèse et/ou à une prolifération cellulaire indésirables, telles que la rétinopathie diabétique, le glaucome néovasculaire, l'arthrite rhumatoïde et le psoriasis, par l'administration de quantités efficaces de ces composés.
Reich Siegfried Heinz
Wallace Michael B.
Agouron Pharmaceuticals Inc.
Smart & Biggar
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