Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) C07D 207/34 (2006.01) C07D 403/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 477/20 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2099817

ABSTRACT ANTIBIOTIC COMPOUNDS The present invention relates to carbapenems and provides a compound of the formula (I) Image (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; A is a 5-membered heteroaryl ring containing one nitrogen atom and up to two additional heteroatoms selected from nitrogen, oxygen and sulphur; and is bonded to the nitrogen of the linking carbamoyl group by a carbon atom in the ring, is substituted with the carboxy group on a carbon atom in the ring and is optionally further substituted on a carbon atom in the ring; and in any ring -NH-, H is optionally replaced by C1-4alkyl; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.

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