C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/24 (2006.01) A61K 31/155 (2006.01) A61P 25/24 (2006.01) C07C 279/22 (2006.01) C07D 207/09 (2006.01) C07D 209/14 (2006.01) C07D 211/16 (2006.01) C07D 211/26 (2006.01) C07D 211/58 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 213/40 (2006.01) C07D 217/06 (2006.01) C07D 233/61 (2006.01) C07D 235/30 (2006.01) C07D 295/20 (2006.01) C07D 295/215 (2006.01) C07D 333/20 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07D 471/10 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2425285
Novel amidino-urea 5-HT7 receptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites, or prodrugs thereof.
L'invention concerne de nouveaux ligands du récepteur 5-HT¿7? amidino-urée, de formule (1), les variables de cette formule étant telles que définies dans la description, ainsi que des sels, des solvates, des métabolites actifs ou des promédicaments pharmaceutiquement acceptables issus de ces ligands. L'invention concerne également des procédés de préparation de ces ligands, des composés intermédiaires servant à préparer ces ligands, des compositions pharmaceutiques comprenant ces ligands, ainsi que des méthodes pour traiter troubles du sommeil, douleur, dépression ou schizophrénie au moyen de ces ligands.
Hong Yufeng
Kuki Atsuo
Luthin David Robert
Peng Zhengwei
Tompkins Eileen Valenzuela
Sim & Mcburney
Warner-Lambert Company Llc
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