C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12P 21/08 (2006.01) C07K 14/72 (2006.01)
Patent
CA 2646406
The invention relates to antibodies which bind to insulin like growth factor receptor -1 (IGF-IR) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-lR-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-I) and insulin like growth factor 2 (IGF-2) to bind to IGF-IR, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.
La présente invention concerne des anticorps qui se lient au récepteur du facteur de croissance de type insuline 1 (IGF-1R), ainsi que des utilisations de ceux-ci, notamment pour diagnostiquer et traiter un cancer. Cette invention concerne aussi des anticorps monoclonaux humains et murins spécifiques qui inhibent les voies de pro-survie et de prolifération tumorale à médiation par IGF-1R, ainsi que des variantes, des fragments et des dérivés de ceux-ci. Elle concerne également des anticorps monoclonaux humains et murins spécifiques qui bloquent la capacité des ligands, tels que le facteur de croissance de type insuline 1 (IGF-1) et le facteur de croissance de type insuline 2 (IGF-2), à se lier à IGF-1R, ainsi que des fragments, des variantes et des dérivés de ceux-ci. L'invention concerne aussi des polynucléotides codant lesdits anticorps ou fragments, variantes ou dérivés de ceux-ci, ainsi que des vecteurs et des cellules hôtes comprenant de tels polynucléotides. En outre, cette invention concerne des procédés permettant de diagnostiquer et de traiter un cancer au moyen desdits anticorps.
Demarest Stephen
Garber Ellen
Glaser Scott
Graff Christilyn
Hariharan Kandasamy
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
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