Pyrane derivatives as both ace- and nep- inhibitors

Details Pyrane derivatives as both ace- and nep- inhibitors Pyrane derivatives as both ace- and nep- inhibitors

C - Chemistry, Metallurgy

07

D

C07D 309/06 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2456281

Compounds of the formula (I), wherein R1, R1-R7 and alk have meaning as defined, pharmaceutical compositions thereof, and use thereof for the treatment and/or prevention of cardiovascular disorders responsive to ACE and NEP inhibition and/or ECE inhibition.

L'invention concerne des composés de formule (I), dans laquelle R¿1?, R¿1?-R¿7? et alk ont les désignations spécifiées, ainsi que des compositions pharmaceutiques de ces produits et l'utilisation de celles-ci pour le traitement et/ou la prévention de maladies cardiovasculaires sensibles à l'inhibition de ACE et NEP et/ou à l'inhibition de ECE.

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