Taste masked pharmaceutical compositions comprising bitter...

A - Human Necessities – 61 – K

Patent

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A61K 9/16 (2006.01)

Patent

CA 2549572

The present invention discloses pharmaceutical compositions comprising of pH sensitive polymers used for taste masking highly bitter drugs. The pH sensitive polymer acts as a reverse enteric coating, which is soluble in the acidic pH range 1.0 to 3.0 normally found in the stomach but is insoluble in the pH range 3.5 to 7 thus inhibiting the release of the bitter drug at the pH of saliva and also at the pH of reconstitution medium in case of liquid orals.

La présente invention a trait à des compositions pharmaceutiques comportant des polymères sensible au pH utilisés pour masquer le goût de médicaments très amers. Le polymère sensible au pH agit comme un enrobage entérique inverse, qui est soluble dans la plage de pH acide comprise entre 1,0 et 3,0 présente dans l'estomac mais est insoluble dans la plage de pH comprise entre 3,5 et 7 assurant ainsi l'inhibition de la libération du médicament amer au niveau du pH de la salive et également au niveau du pH du milieu de reconstitution dans le cas des liquides buccaux.

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