Human endokine alpha and methods of use

Details Human endokine alpha and methods of use Human endokine alpha and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61P 25/00 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2363779

The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

L'invention concerne un nouveau membre de la famille de cytokines de facteur de nécrose tumorale (TNF). Cette invention concerne notamment des molécules d'acides nucléiques isolées codant la protéine alpha endokine, ainsi que des polypeptides endokine alpha, des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant de les produire. Ladite invention concerne aussi des méthodes diagnostiques et thérapeutiques relatives aux troubles liés à la famille TNF.

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