Glucagon receptor antagonists, compositions, and methods for...

Details Glucagon receptor antagonists, compositions, and methods for... Glucagon receptor antagonists, compositions, and methods for...

C - Chemistry, Metallurgy

07

D

C07D 231/22 (2006.01) A61K 31/415 (2006.01) C07D 231/38 (2006.01)

Patent

CA 2724294

The present invention relates to compounds of general formula (I), wherein ring A, ring B, R1, R2, R3, Z, and L1 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

La présente invention concerne les composés représentés par la formule générale (I). Dans cette formule, le cycle A, le cycle B, R1, R2, R3, Z, et L1 sont sélectionnés indépendamment les uns des autres et sont tels que définis dans la description. L'invention concerne aussi des compositions comprenant ces composés et des procédés d'utilisation de ces composés comme antagonistes du récepteur de glucagon et pour le traitement ou la prévention du diabète de type 2 et des états associés à ce diabète.

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