An integrin heterodimer and a subunit thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2324381

A recombinant or isolated integrin heterodimer comprising a novel subunit .alpha.10 in association with a subunit .beta. is described. The .alpha.10 integrin may be purified from bovine chondrocytes on a collagen-type-II affinity column. The integrin or the subunit .alpha.10 can be used as marker or target of all types of cells, e.g. of chondrocytes, osteoblasts and fibroblasts. The integrin or subunit .alpha.10 thereof can be used as marker or target in different physiological or therapeutic methods. They can also be used as active ingredients in pharmaceutical compositions and vaccines.

L'invention concerne un hétérodimère d'intégrine recombiné ou isolé comprenant une nouvelle sous-unité .alpha.10 en association avec une sous-unité .beta.. L'intégrine .alpha.10 peut être purifiée à partir de chondrocytes de bovins sur une colonne d'affinité de type II de collagène. On peut utiliser l'intégrine ou sa sous-unité .alpha.10 comme marqueur ou cible pour tous types de cellules, par exemple des cellules de chondrocytes, d'ostéoblastes et de fibroblastes. On peut donc utiliser l'intégrine ou sa sous-unité .alpha.10 comme marqueur ou cible dans diverses méthodes physiologiques ou thérapeutiques. On peut également les utiliser comme ingrédients actifs dans des compositions pharmaceutiques et des vaccins.

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