Methods involving the use of capg as a diagnostic marker and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/00 (2006.01) A61K 39/00 (2006.01) C12Q 1/25 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2440623

The present invention relates to the identification of capG as a critical enzyme in the process of RANKL-induced osteoclast-activation. The present invention includes modulators of capG and assays for the identification of such modulators, as well as the use of such modulators in the treatment and prevention of osteoporosis and related disease states.

L'invention concerne l'identification de l'enzyme capG comme enzyme déterminant dans le processus de l'activation des ostéoclastes induite par le ligand RANKL. L'invention concerne également des modulateurs de capG, et des dosages pour l'identification de ces modulateurs, ainsi que l'utilisation des modulateurs en question dans le traitement et la prévention de l'ostéoporose et des maladies connexes.

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