C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2417152
The present invention provides synthetic compounds based on amino acid residues (700-708) of the native human cancer antigen protease activated receptor-3 (PAR-3), antibodies that recognize and bind to these compounds, polymucleotides that encode these compounds, and immune effector cells raised in response to presentation of these epitopes. The invention further provides methods for inducing an immune response and administering immunotherapy to a subject by delivering the compositions of the invention.
La présente invention concerne des composés synthétiques, des anticorps qui reconnaissent ces composés et se lient à eux, des polynucléotides qui codent ces composés et des cellules immunitaires effectrices produites en réponse à la présentation de ces épitopes. L'invention se rapporte également à des procédés permettant d'induire une réponse immunitaire chez un sujet et de le soumettre à une immunothérapie en lui administrant les compositions de l'invention.
Genzyme Corporation
Gowling Lafleur Henderson Llp
LandOfFree
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