Purine derivatives for use as adenosin a-2a receptor agonists

Details Purine derivatives for use as adenosin a-2a receptor agonists Purine derivatives for use as adenosin a-2a receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 29/00 (2006.01) C07D 473/32 (2006.01) C07D 473/40 (2006.01)

Patent

CA 2582434

Compounds of formula (I) in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Cette invention concerne les composés représentés par la formule (I) sous forme libre ou sous forme de sel. Dans cette formule, R1, R2 et R3 sont tels que définis dans la spécification. Ces composés peuvent être utilisés pour traiter des états induits par l'activation du récepteur A2A de l'adénosine, en particulier des maladies inflammatoires ou obstructives des voies aériennes. Cette invention concerne également des compositions pharmaceutiques qui contiennent ces composés et un procédé de préparation de ces composés.

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