Novel isoamido-substituted hydroxy-6-phenylphenanthridines...

C - Chemistry – Metallurgy – 07 – D

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C07D 221/12 (2006.01) A61K 31/473 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2558375

Compounds of a certain formula (I), in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C- cycloalkoxy, 3-7C-cycloalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly flurorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, either, in a first embodiment (embodiment) according to the present invention, R4 is -O-R41, in which R41 is hydrogen, 1-4C-alkyl, 1-4C- alkoxy-1-4C-alkyl, hydroxy-2-4C-alkyl, 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, and R5 is hydrogen or 1-4C- alkyl, or, in a second embodiment (embodiment b) according to the present invention, R4 is hydrogen or 1-4C-alkyl, and R5 is -O-R51, in which R51 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, hydroxy-2-4C-alkyl, 1-7C- alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, R6 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R61 is hydrogen, 1-4C- alkyl or 1-4C-alkoxy-2-4C-alkyl, R7 is Het1, Har1, 3-7C-cycloalkyl, or 1-4C- alkyl substituted by R8, are novel effective PDE4 inhibitors.

La présente invention concerne des composés représentés par la formule (I), dans laquelle, R1, R2, R3, R31, R4, R5, R6, R61 et R7 sont tels que définis dans la description. Les composés décrits dans cette invention sont des nouveaux inhibiteurs de PDE4 efficaces.

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