G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2685830
The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.
La présente invention concerne entre autres des immunodosages présentant une interréactivité réduite avec des métabolites d'analyte. En outre, la présente invention concerne des immunodosages de diagnostic pour déterminer la concentration ou le taux dans un échantillon d'essai d'un médicament hydrophobe qui se métabolise in vivo ou in vitro pour former des métabolites inter-réactifs où l'interréactivité avec de tels métabolites de l'analyte de médicament est réduite. En particulier, l'invention concerne de tels immunodosages où le médicament hydrophobe est un médicament immunosuppresseur tel que la cyclosporine A.
Brate Elaine M.
Finley David M.
Holets-Mccormack Shelley R.
Pacenti David P.
Piktel Ryan E.
Abbott Laboratories
Gowling Lafleur Henderson Llp
LandOfFree
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