Tri-substituted phenyl derivatives useful as pde iv inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 213/56 (2006.01) A61K 31/33 (2006.01) A61K 31/44 (2006.01) C07D 207/337 (2006.01) C07D 213/40 (2006.01) C07D 213/89 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2241093

Compounds of general formula (1) are described, wherein W, L, R3, R4, R5, R6 and R7 have the meanings as defined in the description, according to which at least one of R4 or R5 is a -(CH2)t ArN(R b)CX1N(R b)L2(Alk)m Ar group. The compounds are phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

L'invention concerne des composés ayant la formule générale (1). Dans cette formule, W, L, R<3>, R<4>, R<5>, R<6> et R<7> ont les significations données dans la description. En particulier au moins un des groupes R<4> ou R<5> est un groupe -(CH2)tArN(R<b>)CX<1>N(R<b>)L<2>(Alk)mAr. Les composés sont des inhibiteurs de la phosphodiestérase de la classe IV et ils sont utiles pour prévenir et traiter des maladies telles que l'asthme accompagné d'une réponse inflammatoire indésirable ou d'un spasme musculaire.

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